|
KMID : 1094720190240030529
|
|
Biotechnology and Bioprocess Engineering
2019 Volume.24 No. 3 p.529 ~ p.535
|
|
|
Characteristics and Mechanism of Microwave-assisted Drying of Amorphous Paclitaxel for Removal of Residual Solvent
|
|
Jang Won-Seok
Kim Jin-Hyun
|
|
|
Abstract
|
|
|
|
We investigated the characteristics and mechanism of microwave-assisted drying of amorphous paclitaxel for the removal of residual solvent, acetonitrile. The removal efficiency of residual acetonitrile increased with increasing drying temperature from 35 to 55°C. When the experimental data were applied to typical kinetic models, the Page model was determined to be the most suitable. Thermodynamic parameters revealed the spontaneous and endothermic nature of microwave-assisted drying. The effective diffusion coefficient of acetonitrile (0.865 × 10?8∼ 1.553 × 10?8 m2/s) and the convective mass transfer coefficient (2.138 × 10?7∼7.656 × 10?7 m/s) increased with increasing drying temperature. The small Biot number (0.001975∼ 0.003939) indicated that the process of mass transfer was externally controlled.
|
|
|
KEYWORD
|
|
|
amorphous paclitaxel, microwave-assisted drying, characteristics, effective diffusivity, mass transfer coefficient
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|